CD26 Expression on T Helper Populations and sCD26 Serum Levels in Patients with Rheumatoid Arthritis
2015
Details
- Autor(en) / Beteiligte
- Titel
- CD26 Expression on T Helper Populations and sCD26 Serum Levels in Patients with Rheumatoid Arthritis
- Ist Teil von
- PloS one, 2015-07, Vol.10 (7), p.e0131992-e0131992
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- We studied dipeptidyl peptidase IV (DPP-IV, CD26) expression in different T helper cells and serum soluble DPP-IV/sCD26 levels in rheumatoid arthritis (RA) patients, correlated these with disease activity score (DAS), and examined how they were affected by different therapies, conventional or biological (anti-TNF, anti-CD20 and anti-IL6R or Ig-CTLA4). The percentage of CD4+CD45R0+CD26- cells was greatly reduced in patients (up to 50%) when compared with healthy subjects. Three other subsets of CD4 cells, including a CD26high Th1-associated population, changed variably with therapies. Data from these subsets (frequency and staining density) significantly correlated with DAS28 or DAS28 components but different in each group of patients undergoing the different therapies. Th17 and Th22 subsets were implicated in RA as independent CCR4+ and CCR4- populations each, with distinct CD26 expression, and were targeted with varying efficiency by each therapy. Serum DPP-IV activity rather than sCD26 levels was lower in RA patients compared to healthy donors. DPP-IV and sCD26 serum levels were found related to specific T cell subsets but not to disease activity. We conclude that, according to their CD26 expression, different cell subsets could serve to monitor RA course, and an uncharacterized T helper CD26- subset, not targeted by therapies, should be monitored for early diagnosis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0131992Titel-ID: cdi_plos_journals_1696689271
- Format
- –
- Schlagworte
- Adult, Antirheumatic Agents - therapeutic use, Arthritis, Arthritis, Rheumatoid - blood, Arthritis, Rheumatoid - drug therapy, Arthritis, Rheumatoid - genetics, Arthritis, Rheumatoid - physiopathology, Biochemistry, Biomarkers, CD20 antigen, CD4 antigen, CD4-Positive T-Lymphocytes - cytology, CD4-Positive T-Lymphocytes - immunology, CD4-Positive T-Lymphocytes - metabolism, CTLA-4 protein, Cytokines, Demography, Dipeptidyl Peptidase 4 - blood, Dipeptidyl Peptidase 4 - genetics, Dipeptidyl Peptidase 4 - metabolism, Dipeptidyl-peptidase IV, Female, Gene Expression Regulation, Helper cells, Humans, Immunoglobulins, Immunology, Interleukin 6, Interleukin 6 receptors, Leukocyte Common Antigens - metabolism, Lung diseases, Lymphocytes, Lymphocytes T, Male, Middle Aged, Molecular biology, Multiple sclerosis, Pathogenesis, Patients, Peptidase, Populations, Rheumatoid arthritis, Rheumatology, Serum levels, Severity of Illness Index, T-Lymphocyte Subsets - cytology, T-Lymphocyte Subsets - metabolism, T-Lymphocytes, Helper-Inducer - cytology, T-Lymphocytes, Helper-Inducer - immunology, T-Lymphocytes, Helper-Inducer - metabolism, Th17 Cells - cytology, Th17 Cells - immunology, Tumors