PloS one, 2015-05, Vol.10 (5), p.e0126390-e0126390
2015
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- Autor(en) / Beteiligte
- Titel
- Novel antimicrobial peptides with high anticancer activity and selectivity
- Ist Teil von
- PloS one, 2015-05, Vol.10 (5), p.e0126390-e0126390
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We describe a strategy to boost anticancer activity and reduce normal cell toxicity of short antimicrobial peptides by adding positive charge amino acids and non-nature bulky amino acid β-naphthylalanine residues to their termini. Among the designed peptides, K4R2-Nal2-S1 displayed better salt resistance and less toxicity to hRBCs and human fibroblast than Nal2-S1 and K6-Nal2-S1. Fluorescence microscopic studies indicated that the FITC-labeled K4R2-Nal2-S1 preferentially binds cancer cells and causes apoptotic cell death. Moreover, a significant inhibition in human lung tumor growth was observed in the xenograft mice treated with K4R2-Nal2-S1. Our strategy provides new opportunities in the development of highly effective and selective antimicrobial and anticancer peptide-based therapeutics.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0126390Titel-ID: cdi_plos_journals_1680707019
- Format
- –
- Schlagworte
- Amino acids, Animals, Anti-Bacterial Agents - pharmacology, Antibiotics, Antineoplastic - pharmacology, Anticancer properties, Antiinfectives and antibacterials, Antimicrobial agents, Antimicrobial Cationic Peptides - pharmacology, Antimicrobial peptides, Antitumor activity, Apoptosis, Bacteria, Biomedical materials, Biotechnology, Cancer, Cancer therapies, Cancer treatment, Cell death, Cell Line, Tumor, Design, Drug resistance, Escherichia coli - drug effects, Fluorescence, Gangrene, Humans, Innovations, Lung Neoplasms - drug therapy, Lungs, Male, Mice, Inbred BALB C, Mice, Nude, Microbial Sensitivity Tests, Molecular targeted therapy, Peptides, Physiology, Properties, Prostate, Pseudomonas aeruginosa, Pseudomonas aeruginosa - drug effects, Salts, Science, Staphylococcus aureus - drug effects, Toxicity, Xenograft Model Antitumor Assays, Xenografts