PloS one, 2015-04, Vol.10 (4), p.e0124251-e0124251
2015
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- Autor(en) / Beteiligte
- Titel
- High SEPT9_i1 protein expression is associated with high-grade prostate cancers
- Ist Teil von
- PloS one, 2015-04, Vol.10 (4), p.e0124251-e0124251
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2015
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Septins are a family of GTP-binding cytoskeleton proteins expressed in many solid tumors. Septin 9 (SEPT9) in particular was found overexpressed in diverse carcinomas. Herein, we studied the expression of SEPT9 isoform 1 protein (SEPT9_i1) in human prostate cancer specimens. We utilized immunohistochemical staining to study the expression of SEPT9_i1 protein. Staining level was analyzed in association with clinical characteristics and the pathological Gleason grade and score. Fifty human prostate cancer specimens (42 primary tumors and 8 metastatic lesions) were stained by SEPT9_i1 antibody and analyzed. SEPT9_i1 protein was expressed in prostate cancer cells but absent in normal epithelial cells. The intensity of staining was correlated proportionally to pretreatment prostate-specific antigen (PSA) blood levels and Gleason score (P < 0.05). SEPT9_i1 was highly expressed in all metastatic lesions. A significant assocation between SEPT9_i1 expression and high Gleason score on multivariate linear regression analysis was found. We conclude that SEPT9_i1 is expressed in high-grade prostate tumors suggesting it has a significant role in prostate tumorigenesis and that it could serve as a molecular marker for prostate tumor progression.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0124251Titel-ID: cdi_plos_journals_1674683871
- Format
- –
- Schlagworte
- Adenocarcinoma - enzymology, Adenocarcinoma - secondary, Aged, Aged, 80 and over, Angiogenesis, Biomarkers, Tumor - metabolism, Blood levels, Bone Neoplasms - enzymology, Bone Neoplasms - secondary, Cancer, Cancer therapies, Carcinoma, Cytoskeleton, Disease Progression, Epithelial cells, Gene therapy, GTP, Guanosine triphosphate, Humans, Hypoxia, Immunoglobulins, Immunohistochemistry, Isoenzymes - metabolism, Lesions, Lymphatic system, Male, Metastases, Metastasis, Middle Aged, Motility, Neoplasm Grading, Pathology, Pretreatment, Prostate, Prostate cancer, Prostate-specific antigen, Prostatic Neoplasms - enzymology, Prostatic Neoplasms - pathology, Protein binding, Protein expression, Proteins, Quality, Regression analysis, Retrospective Studies, Septin, Septins - metabolism, Solid tumors, Staining, Surveillance, Tumorigenesis, Tumors, Urology