PloS one, 2015-04, Vol.10 (4), p.e0122893-e0122893
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Effects of dietary supplementation with glutamate and aspartate on diquat-induced oxidative stress in piglets
- Ist Teil von
- PloS one, 2015-04, Vol.10 (4), p.e0122893-e0122893
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- This study aimed to investigate the protective effects of dietary glutamate and aspartate supplementations on diquat-induced oxidative stress in piglets. Diquat injection significantly reduced growth performance, including body weight, average daily weight gain, and feed intake (P<0.05). Meanwhile, diquat administration induced oxidative stress evidenced by the decreased serum nitric oxide (NO) and elevated malondialdeyhde (MDA) concentration (P<0.05). Furthermore, diquat-induced oxidative stress disrupted intestinal absorption system and decreased serum threonine, serine, and glycine levels. Dietary supplementation with glutamate improved final body weight, antioxidant system, and expressions of amino acids transporters and enhanced serum glutamate concentration compared with diquat group (P<0.05). While aspartate failed to alleviate diquat-induced oxidative stress, growth depression, and dysfunction of nutrients absorption except for liver relative weight. In conclusion, dietary supplementation with glutamate confers beneficial effects on diquat-induced oxidative stress in piglets, while aspartate exhibits little effects.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0122893Titel-ID: cdi_plos_journals_1673378988
- Format
- –
- Schlagworte
- Absorption, Amino acids, Amino Acids - blood, Analysis, Animal sciences, Animals, Animals, Newborn, Antioxidants, Antioxidants (Nutrients), Antioxidants - metabolism, Aspartate, Aspartic Acid - administration & dosage, Aspartic Acid - pharmacology, Body weight, Body Weight - drug effects, Body weight gain, Cationic Amino Acid Transporter 1 - genetics, Diet, Dietary Supplements, Diquat, Diquat - administration & dosage, Diquat - toxicity, Engineering research, Excitatory Amino Acid Transporter 3 - genetics, Feed science, Feeds, Gene Expression - drug effects, Glutamate, Glutamic Acid - administration & dosage, Glutamic Acid - pharmacology, Glycine, Growth rate, Herbicides - administration & dosage, Herbicides - toxicity, Hogs, Intestinal absorption, Intestine, Intestines - drug effects, Intestines - metabolism, Laboratories, Liver, Livestock, Malondialdehyde - blood, Metabolism, Nitric oxide, Nitric Oxide - blood, Nutrients, Nutrition research, Oxidative stress, Oxidative Stress - drug effects, Proteins, Reverse Transcriptase Polymerase Chain Reaction, Rodents, Serine, Stress analysis, Superoxide Dismutase - blood, Swine, Threonine, Weaning, Weight reduction, Zoology