PloS one, 2015-03, Vol.10 (3), p.e0120544-e0120544
2015
Details
- Autor(en) / Beteiligte
- Titel
- Clinical outcomes and microbiological characteristics of severe pneumonia in cancer patients: a prospective cohort study
- Ist Teil von
- PloS one, 2015-03, Vol.10 (3), p.e0120544-e0120544
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Pneumonia is the most frequent type of infection in cancer patients and a frequent cause of ICU admission. The primary aims of this study were to describe the clinical and microbiological characteristics and outcomes in critically ill cancer patients with severe pneumonia. Prospective cohort study in 325 adult cancer patients admitted to three ICUs with severe pneumonia not acquired in the hospital setting. Demographic, clinical and microbiological data were collected. There were 229 (71%) patients with solid tumors and 96 (29%) patients with hematological malignancies. 75% of all patients were in septic shock and 81% needed invasive mechanical ventilation. ICU and hospital mortality rates were 45.8% and 64.9%. Microbiological confirmation was present in 169 (52%) with a predominance of Gram negative bacteria [99 (58.6%)]. The most frequent pathogens were methicillin-sensitive S. aureus [42 (24.9%)], P. aeruginosa [41(24.3%)] and S. pneumonia [21 (12.4%)]. A relatively low incidence of MR [23 (13.6%)] was observed. Adequate antibiotics were prescribed for most patients [136 (80.5%)]. In multivariate analysis, septic shock at ICU admission [OR 5.52 (1.92-15.84)], the use of invasive MV [OR 12.74 (3.60-45.07)] and poor Performance Status [OR 3.00 (1.07-8.42)] were associated with increased hospital mortality. Severe pneumonia is associated with high mortality rates in cancer patients. A relatively low rate of MR pathogens is observed and severity of illness and organ dysfunction seems to be the best predictors of outcome in this population.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0120544Titel-ID: cdi_plos_journals_1666309674
- Format
- –
- Schlagworte
- Aged, Anti-Bacterial Agents - therapeutic use, Antibiotics, Bacterial pneumonia, Cancer, Cancer patients, Cancer research, Cancer therapies, Care and treatment, Clinical outcomes, Cohort analysis, Critical Illness, Demographics, Gram-negative bacteria, Gram-Negative Bacterial Infections - complications, Gram-Negative Bacterial Infections - microbiology, Gram-Negative Bacterial Infections - mortality, Gram-Negative Bacterial Infections - therapy, Hematology, Hospital Mortality, Hospitals, Humans, Infectious diseases, Intensive care, Intensive Care Units, Internal medicine, Invasiveness, Laboratories, Length of Stay, Mechanical ventilation, Medical diagnosis, Medical prognosis, Medicine, Methicillin, Microbiology, Middle Aged, Mortality, Multidrug resistant organisms, Multivariate analysis, Neoplasms - complications, Neoplasms - microbiology, Neoplasms - mortality, Oncology, Experimental, Pathogens, Patient outcomes, Patients, Pneumonia, Pneumonia - complications, Pneumonia - microbiology, Pneumonia - mortality, Pneumonia - therapy, Prospective Studies, Pseudomonas aeruginosa - isolation & purification, Respiration, Artificial, Sepsis, Septic shock, Shock, Septic - complications, Shock, Septic - microbiology, Shock, Septic - mortality, Shock, Septic - therapy, Solid tumors, Staphylococcus aureus - isolation & purification, Streptococcus pneumoniae - isolation & purification, Survival Analysis, Treatment Outcome, Ventilation