PloS one, 2015-03, Vol.10 (3), p.e0121744-e0121744
2015
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Details
- Autor(en) / Beteiligte
- Titel
- STEP levels are unchanged in pre-frontal cortex and associative striatum in post-mortem human brain samples from subjects with schizophrenia, bipolar disorder and major depressive disorder
- Ist Teil von
- PloS one, 2015-03, Vol.10 (3), p.e0121744-e0121744
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Increased protein levels of striatal-enriched tyrosine phosphatase (STEP) have recently been reported in postmortem schizophrenic cortex. The present study sought to replicate this finding in a separate cohort of postmortem samples and to extend observations to striatum, including subjects with bipolar disorder and major depressive disorder in the analysis. No statistically significant changes between disease and control subjects were found in STEP mRNA or protein levels in dorsolateral prefrontal cortex or associative striatum. Although samples were matched for several covariates, postmortem interval correlated negatively with STEP protein levels, emphasizing the importance of including these analyses in postmortem studies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0121744Titel-ID: cdi_plos_journals_1664460199
- Format
- –
- Schlagworte
- Analysis, Autopsy, Bipolar disorder, Bipolar Disorder - enzymology, Bipolar Disorder - genetics, Brain, Brain research, Case-Control Studies, Cortex (frontal), Depressive Disorder, Major - enzymology, Depressive Disorder, Major - genetics, Disease control, Female, Forensic science, Gene expression, Glutamate, Humans, Hypotheses, Major depressive disorder, Male, Mental depression, Mental disorders, Middle Aged, mRNA, Neostriatum, Neostriatum - enzymology, Neurophysiology, Neurosciences, Phosphatase, Phosphatases, Prefrontal cortex, Prefrontal Cortex - enzymology, Protein Tyrosine Phosphatases, Non-Receptor - genetics, Protein Tyrosine Phosphatases, Non-Receptor - metabolism, Protein-tyrosine-phosphatase, Proteins, Psychiatry, R&D, Research & development, RNA, RNA, Messenger - genetics, RNA, Messenger - metabolism, Rodents, Schizophrenia, Schizophrenia - enzymology, Schizophrenia - genetics, Statistical analysis, Statistical methods, Tyrosine