Details

Autor(en) / Beteiligte

• Littnerova, Simona
• Parenica, Jiri
• Spinar, Jindrich
• Vitovec, Jirí
• Linhart, Ales
• Widimsky, Petr
• Jarkovsky, Jiri
• Miklik, Roman
• Spinarova, Lenka
• Zeman, Kamil
• Belohlavek, Jan
• Malek, Filip
• Felsoci, Marian
• Kettner, Jiri
• Ostadal, Petr
• Cihalik, Cestmir
• Spac, Jiri
• Al-Hiti, Hikmet
• Fedorco, Marian
• Fojt, Richard
• Kruger, Andreas
• Malek, Josef
• Mikusová, Tereza
• Monhart, Zdenek
• Bohacova, Stanislava
• Pohludkova, Lidka
• Rohac, Filip
• Vaclavik, Jan
• Vondrakova, Dagmar
• Vyskocilova, Klaudia
• Bambuch, Miroslav
• Dusek, Ladislav
• Rouet, Philippe

Titel

Positive influence of being overweight/obese on long term survival in patients hospitalised due to acute heart failure

Ist Teil von

• PloS one, 2015-02, Vol.10 (2), p.e0117142-e0117142

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Obesity is clearly associated with increased morbidity and mortality rates. However, in patients with acute heart failure (AHF), an increased BMI could represent a protective marker. Studies evaluating the "obesity paradox" on a large cohort with long-term follow-up are lacking. Using the AHEAD database (a Czech multi-centre database of patients hospitalised due to AHF), 5057 patients were evaluated; patients with a BMI <18.5 kg/m2 were excluded. All-cause mortality was compared between groups with a BMI of 18.5-25 kg/m2 and with BMI >25 kg/m2. Data were adjusted by a propensity score for 11 parameters. In the balanced groups, the difference in 30-day mortality was not significant. The long-term mortality of patients with normal weight was higher than for those who were overweight/obese (HR, 1.36; 95% CI, 1.26-1.48; p<0.001)). In the balanced dataset, the pattern was similar (1.22; 1.09-1.39; p<0.001). A similar result was found in the balanced dataset of a subgroup of patients with de novo AHF (1.30; 1.11-1.52; p = 0.001), but only a trend in a balanced dataset of patients with acute decompensated heart failure. These data suggest significantly lower long-term mortality in overweight/obese patients with AHF. The results suggest that at present there is no evidence for weight reduction in overweight/obese patients with heart failure, and emphasize the importance of prevention of cardiac cachexia.