Details

Autor(en) / Beteiligte

• Morgan, Andrew P
• Crowley, James J
• Nonneman, Randal J
• Quackenbush, Corey R
• Miller, Cheryl N
• Ryan, Allison K
• Bogue, Molly A
• Paredes, Sur Herrera
• Yourstone, Scott
• Carroll, Ian M
• Kawula, Thomas H
• Bower, Maureen A
• Sartor, R Balfour
• Sullivan, Patrick F
• Heimesaat, Markus M.

Titel

The antipsychotic olanzapine interacts with the gut microbiome to cause weight gain in mouse

Ist Teil von

• PloS one, 2014-12, Vol.9 (12), p.e115225

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2014

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The second-generation antipsychotic olanzapine is effective in reducing psychotic symptoms but can cause extreme weight gain in human patients. We investigated the role of the gut microbiota in this adverse drug effect using a mouse model. First, we used germ-free C57BL/6J mice to demonstrate that gut bacteria are necessary and sufficient for weight gain caused by oral delivery of olanzapine. Second, we surveyed fecal microbiota before, during, and after treatment and found that olanzapine potentiated a shift towards an "obesogenic" bacterial profile. Finally, we demonstrated that olanzapine has antimicrobial activity in vitro against resident enteric bacterial strains. These results collectively provide strong evidence for a mechanism underlying olanzapine-induced weight gain in mouse and a hypothesis for clinical translation in human patients.