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Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site
Ist Teil von
PloS one, 2014-11, Vol.9 (11), p.e113096-e113096
Ort / Verlag
United States: Public Library of Science
Erscheinungsjahr
2014
Quelle
MEDLINE
Beschreibungen/Notizen
TPX2, a protein involved in mitosis, is considered a good marker for actively proliferating tissues, highly expressed in a number of cancer cells. We show the presence of high-affinity binding site for STAT3 in the 5'-flanking region of the Tpx2 gene, which is in vivo bound by activated STAT3. A specific STAT3 peptide inhibitor represses the expression of the Tpx2 gene and inhibits the binding of STAT3 to its consensus sequence in human cell lines where STAT3 is activated. These results indicate that activated STAT3 contributes to the over-expression of Tpx2 through the binding to an enhancer site.