PloS one, 2014-10, Vol.9 (10), p.e109103-e109103
2014
Details
- Autor(en) / Beteiligte
- Titel
- Characterization of programmed death-1 homologue-1 (PD-1H) expression and function in normal and HIV infected individuals
- Ist Teil von
- PloS one, 2014-10, Vol.9 (10), p.e109103-e109103
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2014
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Chronic immune activation that persists despite anti-retroviral therapy (ART) is the strongest predictor of disease progression in HIV infection. Monocyte/macrophages in HIV-infected individuals are known to spontaneously secrete cytokines, although neither the mechanism nor the molecules involved are known. Here we show that overexpression of the newly described co-stimulatory molecule, PD1 homologue (PD-1H) in human monocyte/macrophages is sufficient to induce spontaneous secretion of multiple cytokines. The process requires signaling via PD-1H as cytokine secretion could be abrogated by deletion of the cytoplasmic domain. Such overexpression of PD-1H, associated with spontaneous cytokine expression is seen in monocytes from chronically HIV-infected individuals and this correlates with immune activation and CD4 depletion, but not viral load. Moreover, antigen presentation by PD-1H-overexpressing monocytes results in enhanced cytokine secretion by HIV-specific T cells. These results suggest that PD-1H might play a crucial role in modulating immune activation and immune response in HIV infection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0109103Titel-ID: cdi_plos_journals_1582256044
- Format
- –
- Schlagworte
- Acquired immune deficiency syndrome, AIDS, Antigen presentation, Apoptosis, B cells, B7 Antigens - metabolism, Biology and Life Sciences, CD4 antigen, CD8-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - metabolism, Cell activation, Chemical properties, Clonal deletion, Cytokines, Cytokines - metabolism, Development and progression, Evaluation, Health aspects, HIV, HIV (Viruses), HIV infection, HIV infections, HIV Infections - immunology, HIV Infections - metabolism, HIV patients, Homology, Human immunodeficiency virus, Humans, Immune response, Immune system, Infection, Infections, Kinases, Lymphocytes, Lymphocytes T, Macrophages, Macrophages - immunology, Macrophages - metabolism, Monocytes, Monocytes - immunology, Monocytes - metabolism, PD-1 protein, Signaling, T cell receptors, T cells, Viral Load - immunology