Details
- Autor(en) / Beteiligte
- Titel
- Xenon impairs reconsolidation of fear memories in a rat model of post-traumatic stress disorder (PTSD)
- Ist Teil von
- PloS one, 2014-08, Vol.9 (8), p.e106189
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2014
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Xenon (Xe) is a noble gas that has been developed for use in people as an inhalational anesthestic and a diagnostic imaging agent. Xe inhibits glutamatergic N-methyl-D-aspartate (NMDA) receptors involved in learning and memory and can affect synaptic plasticity in the amygdala and hippocampus, two brain areas known to play a role in fear conditioning models of post-traumatic stress disorder (PTSD). Because glutamate receptors also have been shown to play a role in fear memory reconsolidation--a state in which recalled memories become susceptible to modification--we examined whether Xe administered after fear memory reactivation could affect subsequent expression of fear-like behavior (freezing) in rats. Male Sprague-Dawley rats were trained for contextual and cued fear conditioning and the effects of inhaled Xe (25%, 1 hr) on fear memory reconsolidation were tested using conditioned freezing measured days or weeks after reactivation/Xe administration. Xe administration immediately after fear memory reactivation significantly reduced conditioned freezing when tested 48 h, 96 h or 18 d after reactivation/Xe administration. Xe did not affect freezing when treatment was delayed until 2 h after reactivation or when administered in the absence of fear memory reactivation. These data suggest that Xe substantially and persistently inhibits memory reconsolidation in a reactivation and time-dependent manner, that it could be used as a new research tool to characterize reconsolidation and other memory processes, and that it could be developed to treat people with PTSD and other disorders related to emotional memory.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0106189Titel-ID: cdi_plos_journals_1557101902
- Format
- –
- Schlagworte
- Activation, Amygdala, Amygdala - drug effects, Animal models, Animals, Aspartate, Behavior, Biology and Life Sciences, Brain, Conditioning, Conditioning, Classical - drug effects, Conditioning, Classical - physiology, Cues, Diagnostic systems, Disease Models, Animal, Emotions - physiology, Extinction, Psychological - drug effects, Fear, Fear - drug effects, Fear - psychology, Fear conditioning, Freezing Reaction, Cataleptic - drug effects, Freezing Reaction, Cataleptic - physiology, Glutamate, Glutamatergic transmission, Glutamic acid receptors (ionotropic), Hippocampus - drug effects, Laboratory animals, Learning, Male, Medical schools, Medicine and Health Sciences, Memory, Memory - drug effects, Memory - physiology, Mental disorders, Methyl aspartate, N-methyl-D-aspartate, N-Methyl-D-aspartic acid receptors, Neuroimaging, Nitrous oxide, Post traumatic stress disorder, Posttraumatic stress disorder, Psychiatry, Rare gases, Rats, Rats, Sprague-Dawley, Receptors, Rodents, Stress Disorders, Post-Traumatic - drug therapy, Stress Disorders, Post-Traumatic - physiopathology, Stress Disorders, Post-Traumatic - psychology, Synaptic plasticity, Tonic immobility, Tranquilizing Agents - pharmacology, Xenon, Xenon - pharmacology