Details

Autor(en) / Beteiligte

• Wang, Fan
• Dai, Weiqi
• Wang, Yugang
• Shen, Miao
• Chen, Kan
• Cheng, Ping
• Zhang, Yan
• Wang, Chengfen
• Li, Jingjing
• Zheng, Yuanyuan
• Lu, Jie
• Yang, Jing
• Zhu, Rong
• Zhang, Huawei
• Zhou, Yingqun
• Xu, Ling
• Guo, Chuanyong
• Chang, Yu-Jia

Titel

The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma

Ist Teil von

• PloS one, 2014-05, Vol.9 (5), p.e97414

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Hepatocellular carcinoma (HCC) is one of the few cancers in which a continuous increase in incidence has been observed over several years. Drug resistance is a major problem in the treatment of HCC. In the present study, we used salinomycin (Sal) and 5-fluorouracil (5-FU) combination therapy on HCC cell lines Huh7, LM3 and SMMC-7721 and nude mice subcutaneously tumor model to study whether Sal could increase the sensitivity of hepatoma cells to the traditional chemotherapeutic agent such as 5-FU. The combination of Sal and 5-FU resulted in a synergistic antitumor effect against liver tumors both in vitro and in vivo. Sal reversed the 5-FU-induced increase in CD133(+) EPCAM(+) cells, epithelial-mesenchymal transition and activation of the Wnt/β-catenin signaling pathway. The combination of Sal and 5-FU may provide us with a new approach to reverse drug resistant for the treatment of patients with HCC.