Details

Autor(en) / Beteiligte

• Gewies, Andreas
• Castineiras-Vilarino, Mercedes
• Ferch, Uta
• Jährling, Nina
• Heinrich, Katja
• Hoeckendorf, Ulrike
• Przemeck, Gerhard K H
• Munding, Matthias
• Groß, Olaf
• Schroeder, Timm
• Horsch, Marion
• Karran, E Loraine
• Majid, Aneela
• Antonowicz, Stefan
• Beckers, Johannes
• Hrabé de Angelis, Martin
• Dodt, Hans-Ulrich
• Peschel, Christian
• Förster, Irmgard
• Dyer, Martin J S
• Ruland, Jürgen
• Liebner, Stefan

Titel

Prdm6 is essential for cardiovascular development in vivo

Ist Teil von

• PloS one, 2013-11, Vol.8 (11), p.e81833

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated from Prdm6-deficient embryonic stem cells and vascular smooth muscle cells were present and proliferated normally in Prdm6-deficient embryos. Conditional deletion of Prdm6 in the smooth muscle cell lineage using a SM22-Cre driver line resulted in perinatal lethality due to hemorrhage in the lungs. We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development.