Details

Autor(en) / Beteiligte

• Seo, Eun Hyun
• Lee, Dong Young
• Lee, Jong-Min
• Park, Jun-Sung
• Sohn, Bo Kyung
• Choe, Young Min
• Byun, Min Soo
• Choi, Hyo Jung
• Woo, Jong Inn
• He, Yong

Titel

Influence of APOE genotype on whole-brain functional networks in cognitively normal elderly

Ist Teil von

• PloS one, 2013-12, Vol.8 (12), p.e83205-e83205

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• This study aimed to investigate the influence of apolipoprotein E (APOE) ε4 allele on whole-brain functional networks in cognitively normal (CN) elderly by applying graph theoretical analysis to brain glucose metabolism. Eighty-six CN elderly [28 APOE ε4 carriers (ε4+) and 58 non-carriers (ε4-)] underwent clinical evaluation and resting [(18)F] fluorodeoxyglucose positron emission tomography scan. Whole-brain functional networks were constructed from correlations of the 90 regions of interest using the automated anatomical labeling template, and analyzed using graph theoretical approaches. The overall small-world property seen in ε4- was preserved in ε4+. However, both local clustering and path length were lower in ε4+ compared to ε4-. In terms of the hubs of functional networks, ε4+ showed decreased centrality of the right hippocampus but increased centrality of several brain regions associated with the default mode network compared to ε4-. Our results indicate that genetic vulnerability to Alzheimer's disease may alter whole-brain functional networks even before clinical symptoms appear.