Details

Autor(en) / Beteiligte

• Brandenburg, Boerries
• Koudstaal, Wouter
• Goudsmit, Jaap
• Klaren, Vincent
• Tang, Chan
• Bujny, Miriam V
• Korse, Hans J W M
• Kwaks, Ted
• Otterstrom, Jason J
• Juraszek, Jarek
• van Oijen, Antoine M
• Vogels, Ronald
• Friesen, Robert H E
• Digard, Paul

Titel

Mechanisms of hemagglutinin targeted influenza virus neutralization

Ist Teil von

• PloS one, 2013-12, Vol.8 (12), p.e80034-e80034

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Human monoclonal antibodies have been identified which neutralize broad spectra of influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies interfere with infectivity. We distinguish four mechanisms that link the conserved hemagglutinin (HA) epitopes of broadly neutralizing antibodies to critical processes in the viral life cycle. HA-stem binding antibodies can act intracellularly by blocking fusion between the viral and endosomal membranes and extracellularly by preventing the proteolytic activation of HA. HA-head binding antibodies prevent viral attachment and release. These insights into newly identified ways by which the human immune system can interfere with influenza virus infection may aid the development of novel universal vaccines and antivirals.