Details

Autor(en) / Beteiligte

• Zhang, Zong Hong
• Khoo, Aik Aun
• Mihalek, Ivana
• Srinivasan, Narayanaswamy

Titel

Cube - an online tool for comparison and contrasting of protein sequences

Ist Teil von

• PloS one, 2013-11, Vol.8 (11), p.e79480

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• When comparing sequences of similar proteins, two kinds of questions can be asked, and the related two kinds of inference made. First, one may ask to what degree they are similar, and then, how they differ. In the first case one may tentatively conclude that the conserved elements common to all sequences are of central and common importance to the protein's function. In the latter case the regions of specialization may be discriminative of the function or binding partners across subfamilies of related proteins. Experimental efforts - mutagenesis or pharmacological intervention - can then be pointed in either direction, depending on the context of the study. Cube simplifies this process for users that already have their favorite sets of sequences, and helps them collate the information by visualization of the conservation and specialization scores on the sequence and on the structure, and by spreadsheet tabulation. All information can be visualized on the spot, or downloaded for reference and later inspection. http://eopsf.org/cube.