Details

Autor(en) / Beteiligte

• Plaza, Vicente
• Ramos-Barbón, David
• Muñoz, Ana María
• Fortuna, Ana María
• Crespo, Astrid
• Murio, Cristina
• Palomino, Rosa
• Palaniyar, Nades

Titel

Exhaled nitric oxide fraction as an add-on to ACQ-7 for not well controlled asthma detection

Ist Teil von

• PloS one, 2013-10, Vol.8 (10), p.e77085-e77085

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2013

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• The measurement of fractional nitric oxide concentration in exhaled breath (FeNO), a noninvasive indicator of airway inflammation, remains controversial as a tool to assess asthma control. Guidelines currently limit asthma control assessment to symptom and spirometry based appraisals such as the Asthma Control Questionnaire-7 (ACQ-7). We aimed at determining whether adding FeNO to ACQ-7 improves current asthma clinical control assessment, through enhanced detection of not well controlled asthma. Asthmatic subjects, classified as not well controlled as per ACQ-7 on regular clinical practice, were included in a prospective, multicenter fashion, and had their maintenance treatment adjusted on visit 1. On follow-up (visit 2) four weeks later, the subjects were reevaluated as controlled or not well controlled using ACQ-7 versus a combination of FeNO and ACQ-7. Out of 381 subjects enrolled, 225 (59.1%) had not well controlled asthma on visit 2 as determined by ACQ-7, and 264 (69.3%) as per combined FeNO and ACQ-7. The combination of FeNO to ACQ-7 increased by 14.8% the detection of not well controlled asthma following maintenance therapy adjustment. The addition of FeNO to ACQ-7 increased the detectability of not well controlled asthma upon adjustment of maintenance therapy. Adding a measure of airway inflammation to usual symptom and spirometry based scores increases the efficacy of current asthma clinical control assessment.