Details

Autor(en) / Beteiligte

• Svensk, Emma
• Ståhlman, Marcus
• Andersson, Carl-Henrik
• Johansson, Maja
• Borén, Jan
• Pilon, Marc
• Ashrafi, Kaveh

Titel

PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans

Ist Teil von

• PLoS genetics, 2013-09, Vol.9 (9), p.e1003801-e1003801

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• C. elegans PAQR-2 is homologous to the insulin-sensitizing adiponectin receptors in mammals, and essential for adaptation to growth at 15°C, a low but usually acceptable temperature for this organism. By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1). We then show genetic evidence that paqr-2, phosphatidylcholines, sbp-1 and Δ9-desaturases form a cold adaptation pathway that regulates the increase in unsaturated fatty acids necessary to retain membrane fluidity at low temperatures. This model is supported by the observations that the paqr-2 suppressors normalize the levels of saturated fatty acids, and that low concentrations of detergents that increase membrane fluidity can rescue the paqr-2 mutant.