PLoS pathogens, 2013-08, Vol.9 (8), p.e1003545-e1003545
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Nuclear hormone receptor regulation of microRNAs controls innate immune responses in C. elegans
- Ist Teil von
- PLoS pathogens, 2013-08, Vol.9 (8), p.e1003545-e1003545
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathogens via the downstream let-7 family of microRNAs, which directly target SKN-1, a gene downstream of PMK-1. These findings identify nuclear hormone receptors as components of innate immunity that crosstalk with the p38/PMK-1 MAP kinase pathway.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1553-7374, 1553-7366eISSN: 1553-7374DOI: 10.1371/journal.ppat.1003545Titel-ID: cdi_plos_journals_1433017535
- Format
- –
- Schlagworte
- Animals, Biology, Caenorhabditis elegans, Caenorhabditis elegans - genetics, Caenorhabditis elegans - immunology, Caenorhabditis elegans Proteins - genetics, Caenorhabditis elegans Proteins - immunology, DNA-Binding Proteins - genetics, DNA-Binding Proteins - immunology, Genetic aspects, Health aspects, Hormones, Immune response, Immune system, Immunity, Innate - physiology, Infections, Kinases, MAP Kinase Signaling System - genetics, MAP Kinase Signaling System - immunology, Medicine, MicroRNA, MicroRNAs - genetics, MicroRNAs - immunology, Mitogen-Activated Protein Kinases - genetics, Mitogen-Activated Protein Kinases - immunology, Nematodes, Physiological aspects, Receptors, Cytoplasmic and Nuclear - genetics, Receptors, Cytoplasmic and Nuclear - immunology, RNA sequencing, Transcription Factors - genetics, Transcription Factors - immunology, Worms