Details

Autor(en) / Beteiligte

• Deng, Bin
• Zhu, Ji-Min
• Wang, Yi
• Liu, Tao-Tao
• Ding, Yan-Bing
• Xiao, Wei-Ming
• Lu, Guo-Tao
• Bo, Ping
• Shen, Xi-Zhong
• Gangopadhyay, Nupur

Titel

Intratumor hypoxia promotes immune tolerance by inducing regulatory T cells via TGF-β1 in gastric cancer

Ist Teil von

• PloS one, 2013-05, Vol.8 (5), p.e63777-e63777

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2013

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Regulatory T cell (Treg)-mediated immunosuppression represents one of the crucial tumor immune evasion mechanisms and is a main obstacle for successful tumor immunotherapy. Hypoxia, a common feature of solid tumors, has been associated with potentiated immunosuppression, decreased therapeutic response, malignant progression and local invasion. Unfortunately, the link between hypoxia and Treg-mediated immune tolerance in gastric cancer remains poorly understood. In our study, Tregs and hypoxia inducible factor-1α were found to be positively correlated with each other and were increased with the tumor progression. A subsequent in vitro study indicated that supernatants derived from gastric cancer cells under hypoxic condition, could induce the expression of Foxp3 via TGF-β1. These findings confirmed the crucial role of Tregs as a therapeutic target in gastric cancer therapy and provided helpful thoughts for the design of immunotherapy for gastric cancer in the future.