Details

Autor(en) / Beteiligte

• Liou, Ying-Jay
• Wang, Hui-Hung
• Lee, Ming-Ta Michael
• Wang, Sheng-Chang
• Chiang, Hung-Lun
• Chen, Cheng-Chung
• Lin, Ching-Hua
• Chung, Ming-Shun
• Kuo, Chien-Cheng
• Liao, Ding-Lieh
• Wu, Ching-Kuan
• Liu, Chih-Min
• Liu, Yu-Li
• Hwu, Hai-Gwo
• Lai, I-Ching
• Tsai, Shih-Jen
• Chen, Chia-Hsiang
• Liu, Hui-Fen
• Chou, Yi-Chun
• Chen, Chien-Hsiun
• Chen, Yuan-Tsong
• Hong, Chen-Jee
• Wu, Jer-Yuarn
• Zhang, Xiang Yang

Titel

Genome-wide association study of treatment refractory schizophrenia in Han Chinese

Ist Teil von

• PloS one, 2012-03, Vol.7 (3), p.e33598

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• We report the first genome-wide association study of a joint analysis using 795 Han Chinese individuals with treatment-refractory schizophrenia (TRS) and 806 controls. Three loci showed suggestive significant association with TRS were identified. These loci include: rs10218843 (P = 3.04 × 10(-7)) and rs11265461 (P = 1.94 × 10(-7)) are adjacent to signaling lymphocytic activation molecule family member 1 (SLAMF1); rs4699030 (P = 1.94 × 10(-6)) and rs230529 (P = 1.74 × 10(-7)) are located in the gene nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1); and rs13049286 (P = 3.05 × 10(-5)) and rs3827219 (P = 1.66 × 10(-5)) fall in receptor-interacting serine/threonine-protein kinase 4 (RIPK4). One isolated single nucleotide polymorphism (SNP), rs739617 (P = 3.87 × 10(-5)) was also identified to be associated with TRS. The -94delATTG allele (rs28362691) located in the promoter region of NFKB1 was identified by resequencing and was found to associate with TRS (P = 4.85 × 10(-6)). The promoter assay demonstrated that the -94delATTG allele had a significant lower promoter activity than the -94insATTG allele in the SH-SY5Y cells. This study suggests that rs28362691 in NFKB1 might be involved in the development of TRS.