PloS one, 2013-04, Vol.8 (4), p.e59905-e59905
- Huertas-Vazquez, Adriana
- Nelson, Christopher P
- Guo, Xiuqing
- Reinier, Kyndaron
- Uy-Evanado, Audrey
- Teodorescu, Carmen
- Ayala, Jo
- Jerger, Katherine
- Chugh, Harpriya
- Braund, Peter S
- Deloukas, Panos
- Hall, Alistair S
- Balmforth, Anthony J
- Jones, Michelle
- Taylor, Kent D
- Pulit, Sara L
- Newton-Cheh, Christopher
- Gunson, Karen
- Jui, Jonathan
- Rotter, Jerome I
- Albert, Christine M
- Samani, Nilesh J
- Chugh, Sumeet S
- Kronenberg, Florian
2013
Details
- Autor(en) / Beteiligte
- Huertas-Vazquez, Adriana
- Nelson, Christopher P
- Guo, Xiuqing
- Reinier, Kyndaron
- Uy-Evanado, Audrey
- Teodorescu, Carmen
- Ayala, Jo
- Jerger, Katherine
- Chugh, Harpriya
- Braund, Peter S
- Deloukas, Panos
- Hall, Alistair S
- Balmforth, Anthony J
- Jones, Michelle
- Taylor, Kent D
- Pulit, Sara L
- Newton-Cheh, Christopher
- Gunson, Karen
- Jui, Jonathan
- Rotter, Jerome I
- Albert, Christine M
- Samani, Nilesh J
- Chugh, Sumeet S
- Kronenberg, Florian
- Titel
- Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease
- Ist Teil von
- PloS one, 2013-04, Vol.8 (4), p.e59905-e59905
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2013
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Recent genome-wide association studies (GWAS) have identified novel loci associated with sudden cardiac death (SCD). Despite this progress, identified DNA variants account for a relatively small portion of overall SCD risk, suggesting that additional loci contributing to SCD susceptibility await discovery. The objective of this study was to identify novel DNA variation associated with SCD in the context of coronary artery disease (CAD). Using the MetaboChip custom array we conducted a case-control association analysis of 119,117 SNPs in 948 SCD cases (with underlying CAD) from the Oregon Sudden Unexpected Death Study (Oregon-SUDS) and 3,050 controls with CAD from the Wellcome Trust Case-Control Consortium (WTCCC). Two newly identified loci were significantly associated with increased risk of SCD after correction for multiple comparisons at: rs6730157 in the RAB3GAP1 gene on chromosome 2 (P = 4.93×10(-12), OR = 1.60) and rs2077316 in the ZNF365 gene on chromosome 10 (P = 3.64×10(-8), OR = 2.41). Our findings suggest that RAB3GAP1 and ZNF365 are relevant candidate genes for SCD and will contribute to the mechanistic understanding of SCD susceptibility.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0059905Titel-ID: cdi_plos_journals_1330900868
- Format
- –
- Schlagworte
- Adult, Aged, Association analysis, Biology, Biomedical research, Cardiac arrest, Cardiology, Cardiovascular disease, Case-Control Studies, Chromosome 10, Chromosome 2, Consortia, Coronary artery, Coronary artery disease, Coronary Artery Disease - complications, Coronary Artery Disease - genetics, Coronary heart disease, Coronary vessels, Death, Death, Sudden, Cardiac - etiology, Deoxyribonucleic acid, DNA, DNA-Binding Proteins - genetics, Drug overdose, Emergency medical care, Female, Genetic aspects, Genetic Loci, Genetic Predisposition to Disease, Genetic research, Genetic variation, Genome-wide association studies, Genomes, Health care, Heart attacks, Heart diseases, Hospitals, Humans, Introns, Loci, Male, Medicine, Middle Aged, Mortality, Mutation, Physicians, Physiological aspects, Polymorphism, Single Nucleotide, Preventive medicine, Prognosis, Proteins, rab3 GTP-Binding Proteins - genetics, Risk, Risk factors, Science, Single-nucleotide polymorphism, Studies, Sudden cardiac death, Transcription Factors - genetics