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Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance
PloS one, 2013-02, Vol.8 (2), p.e56719-e56719
2013
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Autor(en) / Beteiligte
Titel
Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance
Ist Teil von
  • PloS one, 2013-02, Vol.8 (2), p.e56719-e56719
Ort / Verlag
United States: Public Library of Science
Erscheinungsjahr
2013
Quelle
Free E-Journal (出版社公開部分のみ）
Beschreibungen/Notizen
  • Oxidative phosphorylation in mitochondria is responsible for 90% of ATP synthesis in most cells. This essential housekeeping function is mediated by nuclear and mitochondrial genes encoding subunits of complex I to V of the respiratory chain. Although complex IV is the best studied of these complexes, the exact function of the striated muscle-specific subunit COX6A2 is still poorly understood. In this study, we show that Cox6a2-deficient mice are protected against high-fat diet-induced obesity, insulin resistance and glucose intolerance. This phenotype results from elevated energy expenditure and a skeletal muscle fiber type switch towards more oxidative fibers. At the molecular level we observe increased formation of reactive oxygen species, constitutive activation of AMP-activated protein kinase, and enhanced expression of uncoupling proteins. Our data indicate that COX6A2 is a regulator of respiratory uncoupling in muscle and we demonstrate that a novel and direct link exists between muscle respiratory chain activity and diet-induced obesity/insulin resistance.
Sprache
Englisch
Identifikatoren
ISSN: 1932-6203
eISSN: 1932-6203
DOI: 10.1371/journal.pone.0056719
Titel-ID: cdi_plos_journals_1330889585
Format
–
Schlagworte
AMP, AMP-activated protein kinase, AMP-Activated Protein Kinases - metabolism, Animals, Biology, Body Weight - drug effects, Cardiology, Cytochrome, Diabetes, Diet, High-Fat, Electron transport, Electron Transport - genetics, Electron transport chain, Electron Transport Complex IV - genetics, Electron Transport Complex IV - metabolism, Endocrinology, Energy expenditure, Energy Metabolism - drug effects, Enzyme Activation - drug effects, Gene expression, Glucose, Glucose tolerance, Glucose Tolerance Test, Heart, High fat diet, Homeostasis, In Vitro Techniques, Insulin, Insulin - pharmacology, Insulin resistance, Insulin Resistance - genetics, Internal medicine, Intolerance, Ion Channels - metabolism, Kinases, Medicine, Metabolic disorders, Metabolites, Mice, Mitochondria, Mitochondrial Proteins - metabolism, Mitochondrial Size - drug effects, Models, Biological, Muscle Fatigue - drug effects, Muscle Proteins - genetics, Muscle Proteins - metabolism, Muscle, Skeletal - drug effects, Muscle, Skeletal - enzymology, Muscle, Skeletal - pathology, Muscles, Musculoskeletal system, Obesity, Obesity - genetics, Obesity - prevention & control, Oxidation resistance, Oxidative phosphorylation, Oxygen, Phosphorylation, Physiology, Proteins, Reactive oxygen species, Reactive Oxygen Species - metabolism, Skeletal muscle, Starvation - pathology, Thermogenesis - drug effects, Thinness - metabolism, Uncoupling Protein 1, Weight control

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