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Details

Autor(en) / Beteiligte
Titel
Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells
Ist Teil von
  • PloS one, 2013-02, Vol.8 (2), p.e57137-e57137
Ort / Verlag
United States: Public Library of Science
Erscheinungsjahr
2013
Quelle
Elektronische Zeitschriftenbibliothek (Open access)
Beschreibungen/Notizen
  • The mammalian target of rapamycin (mTOR) kinase is a critical regulator of the differentiation of helper and regulatory CD4+ T cells, as well as memory CD8+ T cells. In this study, we investigated the role of the ERK signaling pathway in regulating mTOR activation in T cells. We showed that activation of ERK following TCR engagement is required for sustained mTOR complex 1 (mTORC1) activation. Absence of kinase suppressor of Ras 1 (KSR1), a scaffold protein of the ERK signaling pathway, or inhibition of ERK resulted in decreased mTORC1 activity following T cell activation. However, KSR1-deficient mice displayed normal regulatory CD4+ T cell development, as well as normal memory CD8+ T cell responses to LCMV and Listeria monocytogenes infection. These data indicate that despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR-dependent T cell differentiation.

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