PloS one, 2012-12, Vol.7 (12), p.e52705-e52705
2012
Details
- Autor(en) / Beteiligte
- Titel
- Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis
- Ist Teil von
- PloS one, 2012-12, Vol.7 (12), p.e52705-e52705
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Autophagy has paradoxical and complex functions in cancer development, and autophagy-related genes (ATG) are key regulators in autophagy. Until now, more than 30 different ATG proteins have been identified in yeast, and their mammalian counterparts also have been reported. Although the roles of a few ATG proteins in cancer have been characterized, the role of ATG10 is almost completely unknown. To investigate the clinicopathological role of ATG10 in colorectal cancer, we analyzed ATG10 expression in colorectal cancer tissues and cell lines. Protein expression analysis showed that ATG10 is highly increased in colorectal cancer (tissue - 18/37 cases, 48%; cell line -8/12 cell lines, 66%). Immunohistochemical analysis with clinicopathological features indicated a strong association of the up-regulation of ATG10 with tumor lymph node metastasis (p = 0.005) and invasion (p<0.001). Moreover, both 5-year disease free survival and overall survival rates of patients bearing tumors that did not express ATG10 were significantly higher than those of patients bearing ATG10-expressing tumors (p = 0.012). Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis indicating that ATG10 may be a potential prognostic maker in colorectal cancer.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0052705Titel-ID: cdi_plos_journals_1327199652
- Format
- –
- Schlagworte
- Aged, Analysis, Autophagy, Autophagy-Related Proteins, Binding sites, Biology, Biotechnology, Breast cancer, Cancer, Cancer metastasis, Cell death, Cell Proliferation, Colorectal cancer, Colorectal carcinoma, Colorectal Neoplasms - genetics, Colorectal Neoplasms - mortality, Colorectal Neoplasms - pathology, Deoxyribonucleic acid, Development and progression, Disease, Disease Progression, DNA, DNA methylation, Enzymes, Extracellular matrix, Female, Gastric cancer, Gene Expression Regulation, Neoplastic, Genes, Genomes, Homeostasis, Humans, Lymph, Lymph nodes, Lymph Nodes - pathology, Lymphatic Metastasis, Lymphatic system, Lymphatic Vessels - pathology, Male, Medical prognosis, Medical research, Medicine, Metabolism, Metastases, Metastasis, Middle Aged, Mutation, Neoplasm Staging, Oncology, Patients, Phagocytosis, Proteins, Regulators, Stomach cancer, Surgery, Survival, Tissues, Tumor cell lines, Tumorigenesis, Tumors, Type 2 diabetes, Ubiquitin-Conjugating Enzymes - genetics, Ubiquitin-Conjugating Enzymes - metabolism, Up-Regulation, Vesicular Transport Proteins, Yeast