PloS one, 2012-09, Vol.7 (9), p.e44099-e44099
2012
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Details
- Autor(en) / Beteiligte
- Titel
- Transposable elements in TDP-43-mediated neurodegenerative disorders
- Ist Teil von
- PloS one, 2012-09, Vol.7 (9), p.e44099-e44099
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2012
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Elevated expression of specific transposable elements (TEs) has been observed in several neurodegenerative disorders. TEs also can be active during normal neurogenesis. By mining a series of deep sequencing datasets of protein-RNA interactions and of gene expression profiles, we uncovered extensive binding of TE transcripts to TDP-43, an RNA-binding protein central to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Second, we find that association between TDP-43 and many of its TE targets is reduced in FTLD patients. Third, we discovered that a large fraction of the TEs to which TDP-43 binds become de-repressed in mouse TDP-43 disease models. We propose the hypothesis that TE mis-regulation contributes to TDP-43 related neurodegenerative diseases.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0044099Titel-ID: cdi_plos_journals_1326546080
- Format
- –
- Schlagworte
- Algorithms, Alzheimer's disease, Amyotrophic lateral sclerosis, Analysis, Animal models, Animals, Biology, Case-Control Studies, Datasets, Degeneration, Deoxyribonucleic acid, Disorders, DNA, DNA Transposable Elements, DNA-Binding Proteins - genetics, Frontal Lobe - pathology, Frontotemporal dementia, Gene expression, Gene Expression Profiling, Gene sequencing, Genes, Genome, Genomes, Humans, Laboratories, Medicine, Methods, Mice, Models, Statistical, Molecular Sequence Data, Mutation, Neurodegeneration, Neurodegenerative diseases, Neurodegenerative Diseases - genetics, Neurogenesis, Neurological diseases, Neurons - metabolism, Neurosciences, Protein Binding, Rats, Ribonucleic acid, RNA, RNA - metabolism, RNA-binding protein, RNA-protein interactions, Transposons