PloS one, 2012-08, Vol.7 (8), p.e44285-e44285
2012
Details
- Autor(en) / Beteiligte
- Titel
- Stromal-to-epithelial transition during postpartum endometrial regeneration
- Ist Teil von
- PloS one, 2012-08, Vol.7 (8), p.e44285-e44285
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- Electronic Journals Library
- Beschreibungen/Notizen
- Endometrium is the inner lining of the uterus which is composed of epithelial and stromal tissue compartments enclosed by the two smooth muscle layers of the myometrium. In women, much of the endometrium is shed and regenerated each month during the menstrual cycle. Endometrial regeneration also occurs after parturition. The cellular mechanisms that regulate endometrial regeneration are still poorly understood. Using genetic fate-mapping in the mouse, we found that the epithelial compartment of the endometrium maintains its epithelial identity during the estrous cycle and postpartum regeneration. However, whereas the stromal compartment maintains its identity during homeostatic cycling, after parturition a subset of stromal cells differentiates into epithelium that is subsequently maintained. These findings identify potential progenitor cells within the endometrial stromal compartment that produce long-term epithelial tissue during postpartum endometrial regeneration.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0044285Titel-ID: cdi_plos_journals_1326503591
- Format
- –
- Schlagworte
- Animals, Apoptosis, beta-Galactosidase - biosynthesis, beta-Galactosidase - genetics, Biology, Cell Differentiation, Cell fate, Cell growth, Cell Proliferation, Cells (biology), Compartments, Developmental biology, Endometrial cancer, Endometrium, Endometrium - cytology, Endometrium - physiology, Epithelial Cells - metabolism, Epithelium, Estrus cycle, Fate maps, Female, Gene Expression, Gene mapping, Genes, Reporter, Genetics, Gynecology, Homeostasis, Kinases, Medicine, Menstrual cycle, Menstruation, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Transgenic, Muscles, Myometrium, Ovarian cancer, Parturition, Physiological aspects, Population, Postpartum, Postpartum Period, Progenitor cells, Receptors, Peptide - genetics, Receptors, Peptide - metabolism, Receptors, Transforming Growth Factor beta - genetics, Receptors, Transforming Growth Factor beta - metabolism, Regeneration, Regeneration (Biology), Rodents, Smooth muscle, Stem cells, Stromal cells, Stromal Cells - cytology, Stromal Cells - physiology, Uterus