Details

Autor(en) / Beteiligte

• Eynon, Nir
• Ruiz, Jonatan R
• Femia, Pedro
• Pushkarev, Vladimir P
• Cieszczyk, Pawel
• Maciejewska-Karlowska, Agnieszka
• Sawczuk, Marek
• Dyatlov, Dmitry A
• Lekontsev, Evgeny V
• Kulikov, Leonid M
• Birk, Ruth
• Bishop, David J
• Lucia, Alejandro
• Garatachea, Nuria

Titel

The ACTN3 R577X polymorphism across three groups of elite male European athletes

Ist Teil von

• PloS one, 2012-08, Vol.7 (8), p.e43132-e43132

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• The ACTN3 R577X polymorphism (rs1815739) is a strong candidate to influence elite athletic performance. Yet, controversy exists in the literature owing to between-studies differences in the ethnic background and sample size of the cohorts, the latter being usually low, which makes comparisons difficult. In this case:control genetic study we determined the association between elite athletic status and the ACTN3 R577X polymorphism within three cohorts of European Caucasian men, i.e. Spanish, Polish and Russian [633 cases (278 elite endurance and 355 power athletes), and 808 non-athletic controls]. The odds ratio (OR) of a power athlete harbouring the XX versus the RR genotype compared with sedentary controls was 0.54 [95% confidence interval (CI): 0.34-0.48; P=0.006]. We also observed that the OR of an endurance athlete having the XX versus the RR genotype compared with power athletes was 1.88 (95%CI: 1.07-3.31; P=0.028). In endurance athletes, the OR of a "world-class" competitor having the XX genotype versus the RR+RX genotype was 3.74 (95%CI: 1.08-12.94; P=0.038) compared with those of a lower ("national") competition level. No association (P>0.1) was noted between the ACTN3 R577X polymorphism and competition level (world-class versus national-level) in power athletes. Our data provide comprehensive support for the influence of the ACTN3 R577X polymorphism on elite athletic performance.