PloS one, 2012-08, Vol.7 (8), p.e43343-e43343
2012
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- RNA inhibition highlights cyclin D1 as a potential therapeutic target for mantle cell lymphoma
- Ist Teil von
- PloS one, 2012-08, Vol.7 (8), p.e43343-e43343
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2012
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important role in the pathogenesis of the disease. In this study, we used RNA interference strategies to examine whether cyclin D1 might serve as a therapeutic target for mantle cell lymphoma. Knocking down cyclin D1 resulted in significant growth retardation, cell cycle arrest, and most importantly, induction of apoptosis. These results mark cyclin D1 as a target for mantle cell lymphoma and emphasize the therapeutic potential hidden in its silencing.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0043343Titel-ID: cdi_plos_journals_1326238614
- Format
- –
- Schlagworte
- Aberration, Antineoplastic Agents - pharmacology, Apoptosis, B cells, Biology, Cancer, CCND1 gene, Cell Cycle, Cell growth, Cell Line, Tumor, Cell Proliferation, Cell Survival, Cyclin D1, Cyclin D1 - metabolism, Cyclin-dependent kinases, DEAD-box RNA Helicases - metabolism, Deoxyribonucleic acid, DNA, Gene Expression Regulation, Neoplastic, Gene Silencing, Growth rate, Health aspects, Hematology, Humans, Immunology, Kinases, Laboratories, Life sciences, Lymphoma, Lymphoma, Mantle-Cell - therapy, Lymphomas, Mantle, Mantle cell lymphoma, Medicine, Nanotechnology, Pathogenesis, Proteins, Ribonuclease III - metabolism, Ribonucleic acid, RNA, RNA - metabolism, RNA Interference, RNA-mediated interference, Therapeutic applications, Translocation