PloS one, 2012-07, Vol.7 (7), p.e41005-e41005
2012
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Details
- Autor(en) / Beteiligte
- Titel
- The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-κB activation by disturbing the interaction of XIAP with RIP2
- Ist Teil von
- PloS one, 2012-07, Vol.7 (7), p.e41005-e41005
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- SHIP-1 is an inositol phosphatase predominantly expressed in hematopoietic cells. Over the ten past years, SHIP-1 has been described as an important regulator of immune functions. Here, we characterize a new inhibitory function for SHIP-1 in NOD2 signaling. NOD2 is a crucial cytoplasmic bacterial sensor that activates proinflammatory and antimicrobial responses upon bacterial invasion. We observed that SHIP-1 decreases NOD2-induced NF-κB activation in macrophages. This negative regulation relies on its interaction with XIAP. Indeed, we observed that XIAP is an essential mediator of the NOD2 signaling pathway that enables proper NF-κB activation in macrophages. Upon NOD2 activation, SHIP-1 C-terminal proline rich domain (PRD) interacts with XIAP, thereby disturbing the interaction between XIAP and RIP2 in order to decrease NF-κB signaling.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0041005Titel-ID: cdi_plos_journals_1326223605
- Format
- –
- Schlagworte
- Apoptosis, Bacteria, Biochemistry, biophysics & molecular biology, Biochimie, biophysique & biologie moléculaire, Biology, Cell activation, Cell Line, Tumor, Chlamydophila pneumoniae, Cytokines, Down-Regulation, Epithelial Cells - cytology, Gene Expression Regulation, Humans, Immune System, Immunology, Infections, Inflammation, Inositol, Inositol Polyphosphate 5-Phosphatases, Kinases, Laboratories, Leukemia, Life sciences, Ligands, Listeria, Lymphocytes, Macrophages, Macrophages - cytology, Macrophages - metabolism, Measles, Medicine, Models, Biological, Monocytes - cytology, Mutation, myo-Inositol-1 (or 4)-monophosphatase, NF-kappa B - metabolism, NF-κB protein, NOD2 protein, Nod2 Signaling Adaptor Protein - metabolism, Phosphatase, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Phosphoric Monoester Hydrolases - metabolism, Phosphorylation, Proline, Protein Structure, Tertiary, Proteins, Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism, Rodents, Sciences du vivant, Ships, Signal Transduction, Signaling, Virology, X-Linked Inhibitor of Apoptosis Protein - metabolism, XIAP protein