Details

Autor(en) / Beteiligte

• Lange, Christian M
• Bibert, Stephanie
• Kutalik, Zoltan
• Burgisser, Philippe
• Cerny, Andreas
• Dufour, Jean-Francois
• Geier, Andreas
• Gerlach, Tilman J
• Heim, Markus H
• Malinverni, Raffaele
• Negro, Francesco
• Regenass, Stephan
• Badenhoop, Klaus
• Bojunga, Jörg
• Sarrazin, Christoph
• Zeuzem, Stefan
• Müller, Tobias
• Berg, Thomas
• Bochud, Pierre-Yves
• Moradpour, Darius
• Polyak, Stephen J.

Titel

A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C

Ist Teil von

• PloS one, 2012-07, Vol.7 (7), p.e40159

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN-α) and ribavirin were determined in 701 patients with chronic hepatitis C. In addition, associations between serum concentrations of 25-hydroxyvitamin D(3) (25[OH]D(3)) and treatment outcome were analysed. CYP27B1-1260 rs10877012 was found to be an independent predictor of sustained virologic response (SVR) in patients with poor-response IL28B genotypes (15% difference in SVR for rs10877012 genotype AA vs. CC, p = 0.02, OR = 1.52, 95% CI = 1.061-2.188), but not in patients with favourable IL28B genotype. Patients with chronic hepatitis C showed a high prevalence of vitamin D insufficiency (25[OH]D(3)<20 ng/mL) during all seasons, but 25(OH)D(3) serum levels were not associated with treatment outcome. Our study suggests a role of bioactive vitamin D (1,25[OH](2)D(3), calcitriol) in the response to treatment of chronic hepatitis C. However, serum concentration of the calcitriol precursor 25(OH)D(3) is not a suitable predictor of treatment outcome.