PloS one, 2012-04, Vol.7 (4), p.e34921
2012
Details
- Autor(en) / Beteiligte
- Titel
- Regulation of p53 stability and apoptosis by a ROR agonist
- Ist Teil von
- PloS one, 2012-04, Vol.7 (4), p.e34921
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0034921Titel-ID: cdi_plos_journals_1324449031
- Format
- –
- Schlagworte
- Activation, Alzheimer's disease, Anticancer properties, Antineoplastic Agents - pharmacology, Apoptosis, Apoptosis - drug effects, Benzamides - pharmacology, Biology, Cancer, Cancer genetics, Cancer treatment, Care and treatment, Cell cycle, Cell Cycle - drug effects, Cell growth, Chemical compounds, Circadian rhythm, Dehydrogenases, Development and progression, Gene Expression Regulation, Neoplastic - drug effects, Genes, Genetic aspects, Genomes, Hep G2 Cells, Humans, Identification, Ligands, Liver cancer, Medicine, Nuclear Receptor Subfamily 1, Group F, Member 1 - agonists, Nuclear Receptor Subfamily 1, Group F, Member 1 - metabolism, Orphans, p53 Protein, Pharmacology, Proteins, SOXC Transcription Factors - genetics, SOXC Transcription Factors - metabolism, Stabilization, Sterols, Tumor proteins, Tumor Suppressor Protein p53 - genetics, Tumor Suppressor Protein p53 - metabolism