PloS one, 2010-12, Vol.5 (12), p.e14320-e14320
2010
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- Autor(en) / Beteiligte
- Titel
- Iota-carrageenan is a potent inhibitor of influenza A virus infection
- Ist Teil von
- PloS one, 2010-12, Vol.5 (12), p.e14320-e14320
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The 2009 flu pandemic and the appearance of oseltamivir-resistant H1N1 influenza strains highlight the need for treatment alternatives. One such option is the creation of a protective physical barrier in the nasal cavity. In vitro tests demonstrated that iota-carrageenan is a potent inhibitor of influenza A virus infection, most importantly also of pandemic H1N1/2009 in vitro. Consequently, we tested a commercially available nasal spray containing iota-carrageenan in an influenza A mouse infection model. Treatment of mice infected with a lethal dose of influenza A PR8/34 H1N1 virus with iota-carrageenan starting up to 48 hours post infection resulted in a strong protection of mice similar to mice treated with oseltamivir. Since alternative treatment options for influenza are rare, we conclude that the nasal spray containing iota-carrageenan is an alternative to neuraminidase inhibitors and should be tested for prevention and treatment of influenza A in clinical trials in humans.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0014320Titel-ID: cdi_plos_journals_1318938696
- Format
- –
- Schlagworte
- Analysis, Animals, Antiviral Agents - pharmacology, Carrageenan, Carrageenan - pharmacology, Clinical trials, Cytomegalovirus, Disease Models, Animal, Dogs, Drug Resistance, Viral, Drug therapy, Drugs, Enzyme Inhibitors - pharmacology, Exo-a-sialidase, Food science, HIV, Human immunodeficiency virus, Humans, In vitro methods and tests, Infection, Infections, Influenza, Influenza A, Influenza A virus - drug effects, Influenza, Human - drug therapy, Inhibitors, Laboratories, Lethal dose, Magnetic Resonance Spectroscopy - methods, Medical research, Mice, Mice, Inbred C57BL, Mutation, Neuraminidase - antagonists & inhibitors, Nose, Oseltamivir, Oseltamivir - pharmacology, Pandemics, Polymers - chemistry, Polysaccharides - chemistry, Prevention, Respiratory system agents, Spectrum analysis, Studies, Swine flu, Swine influenza, Trends, Veterinary medicine, Virology, Virology/Animal Models of Infection, Virology/Antivirals, including Modes of Action and Resistance, Virology/New Therapies, including Antivirals and Immunotherapy, Virus diseases, Viruses