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PLoS genetics, 2008-02, Vol.4 (2), p.e28-e28
2008
Details
- Autor(en) / Beteiligte
- Titel
- Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women
- Ist Teil von
- PLoS genetics, 2008-02, Vol.4 (2), p.e28-e28
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Sex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using DNA pooling. We found a female-specific association with rs7341475, a SNP in the fourth intron of the reelin (RELN) gene (p = 2.9 x 10(-5) in women), with a significant gene-sex effect (p = 1.8 x 10(-4)). We studied rs7341475 in four additional populations, totaling 2,274 cases and 4,401 controls. A significant effect was observed only in women, replicating the initial result (p = 2.1 x 10(-3) in women; p = 4.2 x 10(-3) for gene-sex interaction). Based on all populations the estimated relative risk of women carrying the common genotype is 1.58 (p = 8.8 x 10(-7); p = 1.6 x 10(-5) for gene-sex interaction). The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1553-7404, 1553-7390eISSN: 1553-7404DOI: 10.1371/journal.pgen.0040028Titel-ID: cdi_plos_journals_1313460874
- Format
- –
- Schlagworte
- Adult, Alleles, Asians - genetics, Case-Control Studies, Cell Adhesion Molecules, Neuronal - genetics, Extracellular Matrix Proteins - genetics, Female, Gender differences, Gene Frequency, Genes, Genetic Predisposition to Disease, Genetic Variation, Genetics, Genetics and Genomics, Genome, Human, Homo (Human), Humans, Introns, Jews - genetics, Male, Middle Aged, Nerve Tissue Proteins - genetics, Neurological Disorders, Odds Ratio, Polymorphism, Single Nucleotide, Reelin Protein, Risk Factors, Schizophrenia - etiology, Schizophrenia - genetics, Serine Endopeptidases - genetics, Sex Characteristics, Studies, Whites - genetics, Womens health