PloS one, 2008-10, Vol.3 (10), p.e3381-e3381
2008
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- Autor(en) / Beteiligte
- Titel
- Interleukin-10 promotes pathological angiogenesis by regulating macrophage response to hypoxia during development
- Ist Teil von
- PloS one, 2008-10, Vol.3 (10), p.e3381-e3381
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2008
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Aberrant angiogenesis in the eye is the most common cause of blindness. The current study examined the role of interleukin-10 (IL-10) in ischemia-induced pathological angiogenesis called neovascularization during postnatal development. IL-10 deficiency resulted in significantly reduced pathological retinal angiogenesis. In contrast to the choroicapillaris where IL-10 interferes with macrophage influx, IL-10 did not prevent anti-angiogenic macrophages from migrating to the retina in response to hypoxia. Instead, IL-10 promoted retinal angiogenesis by altering macrophage angiogenic function, as macrophages from wild-type mice demonstrated increased vascular endothelial growth factor (VEGF) and nitric oxide (NO) compared to IL-10 deficient macrophages. IL-10 appears to directly affect macrophage responsiveness to hypoxia, as macrophages responded to hypoxia with increased levels of IL-10 and STAT3 phosphorylation as opposed to IL-10 deficient macrophages. Also, IL-10 deficient macrophages inhibited the proliferation of vascular endothelial cells in response to hypoxia while wild-type macrophages failed to do so. These findings suggest that hypoxia guides macrophage behavior to a pro-angiogenic phenotype via IL-10 activated pathways.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0003381Titel-ID: cdi_plos_journals_1312320814
- Format
- –
- Schlagworte
- Aberration, Angiogenesis, Animals, Blindness, Cancer therapies, Cardiovascular Disorders/Vascular Biology, Cell Biology/Leukocyte Signaling and Gene Expression, Cell Movement, Cell proliferation, Comparative analysis, Cytokines, Diabetes, Diabetic retinopathy, Disease, Endothelial cells, Eye, Eye Diseases, Gene expression, Growth and Development, Hypoxia, Immunology/Innate Immunity, Immunology/Leukocyte Activation, Immunology/Leukocyte Signaling and Gene Expression, Interleukin 10, Interleukin-10 - deficiency, Interleukin-10 - physiology, Interleukins, Ischemia, Macrophages, Macrophages - physiology, Macular degeneration, Medicine, Melanoma, Mice, Mice, Inbred C57BL, Mice, Knockout, Neovascularization, Neovascularization, Pathologic, Newborn babies, Nitric oxide, Ophthalmology/Pediatric Ophthalmology, Ophthalmology/Retinal Disorders, Permeability, Phosphorylation, Retina, Retinal Vessels, Rodents, Stat3 protein, Tumor necrosis factor-TNF, Vascular endothelial growth factor, Vascularization