PloS one, 2011-12, Vol.6 (12), p.e28632-e28632
2011
Details
- Autor(en) / Beteiligte
- Titel
- Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure
- Ist Teil von
- PloS one, 2011-12, Vol.6 (12), p.e28632-e28632
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Host genetic factors may be important determinants of HIV-1 sexual acquisition. We performed a genome-wide association study (GWAS) for host genetic variants modifying HIV-1 acquisition and viral control in the context of a cohort of African HIV-1 serodiscordant heterosexual couples. To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use. We matched couples without HIV-1 seroconversion to those with seroconversion by quantified HIV-1 exposure risk. Logistic regression of single nucleotide polymorphisms (SNPs) for 798 samples from 496 HIV-1 infected and 302 HIV-1 exposed, uninfected individuals was performed to identify factors associated with HIV-1 acquisition. In addition, a linear regression analysis was performed using SNP data from a subset (n = 403) of HIV-1 infected individuals to identify factors predicting plasma HIV-1 concentrations. After correcting for multiple comparisons, no SNPs were significantly associated with HIV-1 infection status or plasma HIV-1 concentrations. This GWAS controlling for HIV-1 exposure did not identify common host genotypes influencing HIV-1 acquisition. Alternative strategies, such as large-scale sequencing to identify low frequency variation, should be considered for identifying novel host genetic predictors of HIV-1 acquisition.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0028632Titel-ID: cdi_plos_journals_1312169263
- Format
- –
- Schlagworte
- Acquired immune deficiency syndrome, Adolescent, Adult, Africa, Eastern - epidemiology, Aged, AIDS, Analysis, Biology, Cancer, Chromosomes, Determinants, Disease transmission, Epidemiology, Exposure, Family Characteristics, Female, Frequency variation, Genes, Genetic aspects, Genetic diversity, Genetic factors, Genetic polymorphisms, Genetic variance, Genetic Variation, Genome-wide association studies, Genome-Wide Association Study, Genomes, Genotype, Genotypes, Haplotypes, Health risks, HIV, HIV (Viruses), HIV Infections - epidemiology, HIV Infections - genetics, HIV Infections - transmission, HIV Infections - virology, HIV Seropositivity - immunology, HIV Seropositivity - virology, HIV-1 - immunology, Human immunodeficiency virus, Humans, Immunology, Infections, Infectious diseases, Lectins, Male, Medical research, Medicine, Middle Aged, Population, Regression analysis, Seroconversion, Sexually transmitted diseases, Single-nucleotide polymorphism, STD, Studies, Viruses, Young Adult