PloS one, 2011-09, Vol.6 (9), p.e24987-e24987
- Beesley, Jonathan
- Pickett, Hilda A
- Johnatty, Sharon E
- Dunning, Alison M
- Chen, Xiaoqing
- Li, Jun
- Michailidou, Kyriaki
- Lu, Yi
- Rider, David N
- Palmieri, Rachel T
- Stutz, Michael D
- Lambrechts, Diether
- Despierre, Evelyn
- Lambrechts, Sandrina
- Vergote, Ignace
- Chang-Claude, Jenny
- Nickels, Stefan
- Vrieling, Alina
- Flesch-Janys, Dieter
- Wang-Gohrke, Shan
- Eilber, Ursula
- Bogdanova, Natalia
- Antonenkova, Natalia
- Runnebaum, Ingo B
- Dörk, Thilo
- Goodman, Marc T
- Lurie, Galina
- Wilkens, Lynne R
- Matsuno, Rayna K
- Kiemeney, Lambertus A
- Aben, Katja K H
- Marees, Tamara
- Massuger, Leon F A G
- Fridley, Brooke L
- Vierkant, Robert A
- Bandera, Elisa V
- Olson, Sara H
- Orlow, Irene
- Rodriguez-Rodriguez, Lorna
- Cook, Linda S
- Le, Nhu D
- Brooks-Wilson, Angela
- Kelemen, Linda E
- Campbell, Ian
- Gayther, Simon A
- Ramus, Susan J
- Gentry-Maharaj, Aleksandra
- Menon, Usha
- Ahmed, Shahana
- Baynes, Caroline
- Pharoah, Paul D
- Muir, Kenneth
- Lophatananon, Artitaya
- Chaiwerawattana, Arkom
- Wiangnon, Surapon
- Macgregor, Stuart
- Easton, Douglas F
- Reddel, Roger R
- Goode, Ellen L
- Chenevix-Trench, Georgia
- Zhang, Lin
2011
Details
- Autor(en) / Beteiligte
- Beesley, Jonathan
- Pickett, Hilda A
- Johnatty, Sharon E
- Dunning, Alison M
- Chen, Xiaoqing
- Li, Jun
- Michailidou, Kyriaki
- Lu, Yi
- Rider, David N
- Palmieri, Rachel T
- Stutz, Michael D
- Lambrechts, Diether
- Despierre, Evelyn
- Lambrechts, Sandrina
- Vergote, Ignace
- Chang-Claude, Jenny
- Nickels, Stefan
- Vrieling, Alina
- Flesch-Janys, Dieter
- Wang-Gohrke, Shan
- Eilber, Ursula
- Bogdanova, Natalia
- Antonenkova, Natalia
- Runnebaum, Ingo B
- Dörk, Thilo
- Goodman, Marc T
- Lurie, Galina
- Wilkens, Lynne R
- Matsuno, Rayna K
- Kiemeney, Lambertus A
- Aben, Katja K H
- Marees, Tamara
- Massuger, Leon F A G
- Fridley, Brooke L
- Vierkant, Robert A
- Bandera, Elisa V
- Olson, Sara H
- Orlow, Irene
- Rodriguez-Rodriguez, Lorna
- Cook, Linda S
- Le, Nhu D
- Brooks-Wilson, Angela
- Kelemen, Linda E
- Campbell, Ian
- Gayther, Simon A
- Ramus, Susan J
- Gentry-Maharaj, Aleksandra
- Menon, Usha
- Ahmed, Shahana
- Baynes, Caroline
- Pharoah, Paul D
- Muir, Kenneth
- Lophatananon, Artitaya
- Chaiwerawattana, Arkom
- Wiangnon, Surapon
- Macgregor, Stuart
- Easton, Douglas F
- Reddel, Roger R
- Goode, Ellen L
- Chenevix-Trench, Georgia
- Zhang, Lin
- Titel
- Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers
- Ist Teil von
- PloS one, 2011-09, Vol.6 (9), p.e24987-e24987
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC). We have carried out fine-mapping of this region in EOC which implicates an association with a single nucleotide polymorphism (SNP) within the TERT promoter. We demonstrate that the minor alleles at rs2736109, and at an additional TERT promoter SNP, rs2736108, are associated with decreased breast cancer risk, and that the combination of both SNPs substantially reduces TERT promoter activity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0024987Titel-ID: cdi_plos_journals_1308800348
- Format
- –
- Schlagworte
- Biology, Breast cancer, Breast Neoplasms - genetics, Cancer, Cancer prevention, Case-Control Studies, Chromosome 5, Cystadenocarcinoma, Serous - genetics, Disease susceptibility, Epidemiology, Female, Gene mapping, Genetic aspects, Genetic diversity, Health aspects, Health risk assessment, Health risks, Humans, Medical research, Medicine, Meta-analysis, Neoplasms, Glandular and Epithelial - genetics, Ovarian cancer, Ovarian carcinoma, Ovarian Neoplasms - genetics, Polymorphism, Polymorphism, Single Nucleotide - genetics, Prevention, Preventive medicine, Prognosis, Single nucleotide polymorphisms, Single-nucleotide polymorphism, Telomerase - genetics, Womens health