Details

Autor(en) / Beteiligte

• Kishida, Kenneth T
• Sandberg, Stefan G
• Lohrenz, Terry
• Comair, Youssef G
• Sáez, Ignacio
• Phillips, Paul E M
• Montague, P Read
• Zars, Troy

Titel

Sub-second dopamine detection in human striatum

Ist Teil von

• PloS one, 2011-08, Vol.6 (8), p.e23291-e23291

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Fast-scan cyclic voltammetry at carbon fiber microelectrodes allows rapid (sub-second) measurements of dopamine release in behaving animals. Herein, we report the modification of existing technology and demonstrate the feasibility of making sub-second measurements of dopamine release in the caudate nucleus of a human subject during brain surgery. First, we describe the modification of our electrodes that allow for measurements to be made in a human brain. Next, we demonstrate in vitro and in vivo, that our modified electrodes can measure stimulated dopamine release in a rat brain equivalently to previously determined rodent electrodes. Finally, we demonstrate acute measurements of dopamine release in the caudate of a human patient during DBS electrode implantation surgery. The data generated are highly amenable for future work investigating the relationship between dopamine levels and important decision variables in human decision-making tasks.