Details

Autor(en) / Beteiligte

• Paixão-Côrtes, Vanessa R
• Meyer, Diogo
• Pereira, Tiago V
• Mazières, Stéphane
• Elion, Jacques
• Krishnamoorthy, Rajagopal
• Zago, Marco A
• Silva, Jr, Wilson A
• Salzano, Francisco M
• Bortolini, Maria Cátira
• O'Rourke, Dennis

Titel

Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9

Ist Teil von

• PloS one, 2011-01, Vol.6 (1), p.e15656-e15656

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2011

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 5'and 3'flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works.