PloS one, 2010-11, Vol.5 (11), p.e15098-e15098
2010
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- Autor(en) / Beteiligte
- Titel
- The burden of hospitalized lower respiratory tract infection due to respiratory syncytial virus in rural Thailand
- Ist Teil von
- PloS one, 2010-11, Vol.5 (11), p.e15098-e15098
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We describe the epidemiology of hospitalized RSV infections for all age groups from population-based surveillance in two rural provinces in Thailand. From September 1, 2003 through December 31, 2007, we enrolled hospitalized patients with acute lower respiratory tract illness, who had a chest radiograph ordered by the physician, from all hospitals in SaKaeo and Nakhom Phanom Provinces. We tested nasopharyngeal specimens for RSV with reverse transcriptase polymerase chain reaction (RT-PCR) assays and paired-sera from a subset of patients with IgG enzyme immunoassay. Rates were adjusted for enrollment. Among 11,097 enrolled patients, 987 (8.9%) had RSV infection. Rates of hospitalized RSV infection overall (and radiographically-confirmed pneumonia) were highest among children aged<1 year: 1,067/100,000 (534/100,000 radiographically-confirmed pneumonia) and 1-4 year: 403/100,000 (222/100,000), but low among enrolled adults aged≥65 years: 42/100,000. Age<1 year (adjusted odds ratio [aOR]=13.2, 95% confidence interval [CI] 7.7, 22.5) and 1-4 year (aOR=8.3, 95% CI 5.0, 13.9) were independent predictors of hospitalized RSV infection. The incidence of hospitalized RSV lower respiratory tract illness among children<5 years was high in rural Thailand. Efforts to prevent RSV infection could substantially reduce the pneumonia burden in children aged<5 years.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0015098Titel-ID: cdi_plos_journals_1292204494
- Format
- –
- Schlagworte
- Adolescent, Adult, Adults, Age, Age Factors, Aged, Biology, Child, Child, Preschool, Children, Collaboration, Confidence intervals, Disease control, Disease prevention, DNA polymerases, Enzyme immunoassay, Enzymes, Epidemiology, Hospital patients, Hospitalization, Hospitalization - statistics & numerical data, Humans, Illnesses, Immunoassay, Immunoglobulin G, Incidence, Infant, Infant, Newborn, Infections, Infectious diseases, Influenza, Medicine, Middle Aged, Patients, Pediatric diseases, Pediatrics, Pneumonia, Pneumonia - complications, Pneumonia - epidemiology, Polymerase chain reaction, Population, Population Surveillance, Provinces, Respiratory syncytial virus, Respiratory Syncytial Virus Infections - complications, Respiratory Syncytial Virus Infections - epidemiology, Respiratory Syncytial Virus Infections - virology, Respiratory Syncytial Viruses - genetics, Respiratory Syncytial Viruses - isolation & purification, Respiratory tract, Respiratory tract diseases, Respiratory tract infection, Respiratory Tract Infections - complications, Respiratory Tract Infections - epidemiology, Respiratory Tract Infections - virology, Reverse Transcriptase Polymerase Chain Reaction, RNA, Viral - genetics, RNA-directed DNA polymerase, Rural areas, Rural Population - statistics & numerical data, Surveillance, Thailand - epidemiology, Vaccines, Viruses, Young Adult