Details

Autor(en) / Beteiligte

• Lin, Dandan
• Liu, Chunliang
• Xue, Mengxing
• Liu, Rengyun
• Jiang, Lan
• Yu, Xiao
• Bao, Guangming
• Deng, Fang
• Yu, Mingjie
• Ao, Jiafu
• Zhou, Yifeng
• Wu, Depei
• Liu, Haiyan
• Navarro, Alfons

Titel

The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia

Ist Teil von

• PloS one, 2010-10, Vol.5 (10), p.e13626-e13626

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2010

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Interleukin-15 (IL-15) plays important roles in the immune system and in the development of hematopoietic cells. Previous studies revealed that five SNPs in IL-15, rs10519612, rs10519613, rs35964658, rs17007695 and rs17015014, were significantly associated with childhood Acute Lymphoblastic Leukemia (ALL) treatment response. In adult ALL, the expression of IL-15 was also correlated with the immunophenotypes of ALL. Therefore, we hypothesize that SNPs of IL-15 might also be associated with adult ALL. We genotyped the above five SNPs of IL-15 gene by PCR-RFLP assays in adult ALL case-control studies. The current study included 121 adult ALL patients and 263 healthy controls. IL-15 genotypes and haplotypes were determined and the associations with the risk of ALL were analyzed by logistic regression. SNPs rs10519612 and rs17007695 were significantly associated with ALL (P = 0.013 and P = 0.001). We observed a 2-fold and 2.4-fold excess risk of developing ALL for the rs10519612 CC and rs17007695 TC genotype carriers compared with non-carriers, respectively. Haplotype analysis revealed that haplotypes ACAC, CAGT and CCAT were significantly associated with adult B-ALL, while haplotype CCAT conferred susceptibility to T-ALL. These findings suggest that IL-15 gene polymorphisms are significantly associated with ALL in adult Chinese population.