PloS one, 2009-02, Vol.4 (2), p.e4519-e4519
2009
Details
- Autor(en) / Beteiligte
- Titel
- Lack of galectin-3 drives response to Paracoccidioides brasiliensis toward a Th2-biased immunity
- Ist Teil von
- PloS one, 2009-02, Vol.4 (2), p.e4519-e4519
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2009
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- There is recent evidence that galectin-3 participates in immunity to infections, mostly by tuning cytokine production. We studied the balance of Th1/Th2 responses to P. brasiliensis experimental infection in the absence of galectin-3. The intermediate resistance to the fungal infection presented by C57BL/6 mice, associated with the development of a mixed type of immunity, was replaced with susceptibility to infection and a Th2-polarized immune response, in galectin-3-deficient (gal3(-/-)) mice. Such a response was associated with defective inflammatory and delayed type hypersensitivity (DTH) reactions, high IL-4 and GATA-3 expression and low nitric oxide production in the organs of infected animals. Gal3(-/-) macrophages exhibited higher TLR2 transcript levels and IL-10 production compared to wild-type macrophages after stimulation with P. brasiliensis antigens. We hypothesize that, during an in vivo P. brasiliensis infection, galectin-3 exerts its tuning role on immunity by interfering with the generation of regulatory macrophages, thus hindering the consequent Th2-polarized type of response.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0004519Titel-ID: cdi_plos_journals_1289983144
- Format
- –
- Schlagworte
- Animals, Antigens, Candida albicans, Cytokines, Dendritic cells, Dermatology, Diseases, Experimental infection, Fungi, Galectin 3 - deficiency, Galectin 3 - immunology, Galectin-3, GATA-3 protein, GATA3 Transcription Factor - analysis, Health aspects, Hypersensitivity, Hypersensitivity (delayed), Immune response, Immune system, Immunity, Immunity, Cellular, Immunoglobulins, Immunology/Immunity to Infections, Immunology/Immunomodulation, Infections, Infectious Diseases/Fungal Infections, Inflammation, Interleukin 10, Interleukin 4, Interleukin-10 - analysis, Interleukin-4 - analysis, Lymphocytes T, Macrophages, Macrophages - immunology, Medical research, Medicine, Experimental, Mice, Mice, Inbred C57BL, Mice, Knockout, Muridae, Nitric oxide, Nitric Oxide - analysis, Organs, Paracoccidioides, Paracoccidioides - immunology, Paracoccidioidomycosis - immunology, RNA, Messenger - analysis, Rodents, Studies, Th2 Cells - immunology, TLR2 protein, Toll-Like Receptor 2 - genetics, Toll-like receptors, Transcription, Tuning