Details
- Autor(en) / Beteiligte
- Titel
- Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome
- Ist Teil von
- PloS one, 2010-04, Vol.5 (4), p.e9948-e9948
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2010
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Xenotropic murine leukemia-related retrovirus (XMRV) is a recently discovered retrovirus that has been linked to human prostate cancer and chronic fatigue syndrome (CFS). Both diseases affect a large fraction of the world population, with prostate cancer affecting one in six men, and CFS affecting an estimated 0.4 to 1% of the population. Forty-five compounds, including twenty-eight drugs approved for use in humans, were evaluated against XMRV replication in vitro. We found that the retroviral integrase inhibitor, raltegravir, was potent and selective against XMRV at submicromolar concentrations, in MCF-7 and LNCaP cells, a breast cancer and prostate cancer cell line, respectively. Another integrase inhibitor, L-000870812, and two nucleoside reverse transcriptase inhibitors, zidovudine (ZDV), and tenofovir disoproxil fumarate (TDF) also inhibited XMRV replication. When combined, these drugs displayed mostly synergistic effects against this virus, suggesting that combination therapy may delay or prevent the selection of resistant viruses. If XMRV proves to be a causal factor in prostate cancer or CFS, these discoveries may allow for rational design of clinical trials.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0009948Titel-ID: cdi_plos_journals_1289444660
- Format
- –
- Schlagworte
- Acquired immune deficiency syndrome, AIDS, Antiretroviral drugs, Antiviral Agents, Breast cancer, Cancer, Cell Line, Tumor, Chronic fatigue syndrome, Clinical trials, Crack propagation, DNA polymerases, Drug approval, Drug Evaluation, Preclinical - methods, Drug therapy, Drugs, Fatigue, Fatigue failure, Fatigue Syndrome, Chronic - virology, Female, Gammaretrovirus - drug effects, HIV, Human immunodeficiency virus, Humans, Infectious Diseases, Infectious Diseases/Antimicrobials and Drug Resistance, Inhibitors, Integrase, Leukemia, Leukemia Virus, Murine - drug effects, Male, Medical research, Microbial Sensitivity Tests, Nucleoside reverse transcriptase inhibitors, Prostate cancer, Prostatic Neoplasms - virology, Pyrrolidinones - pharmacology, Pyrrolidinones - therapeutic use, Raltegravir Potassium, Replication, Retroviridae Infections - drug therapy, RNA-directed DNA polymerase, Synergistic effect, Tenofovir, Tumor Virus Infections - drug therapy, Virology, Virology/Antivirals, including Modes of Action and Resistance, Virus Replication - drug effects, Viruses, World population, Xenotropic, Zidovudine