Details

Autor(en) / Beteiligte

• Alwine, James C
• Condit, Richard C.

Titel

The human cytomegalovirus assembly compartment: a masterpiece of viral manipulation of cellular processes that facilitates assembly and egress

Ist Teil von

• PLoS pathogens, 2012-09, Vol.8 (9), p.e1002878-e1002878

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• [...]components of the ESCRT (endosomal sorting complex required for transport) machinery may associate with the AC. Since ESCRT controls the incorporation of cargo into intraluminal vesicles of multivesicular bodies, this association suggests that the ESCRT machinery may facilitate formation of the multivesicular AC and virion maturation [4]. [...]by commandeering the vesicular secretary components to form the AC, HCMV creates a milieu where tegument proteins can be arranged for ordered application to the maturing virions, which can then be enveloped.\n Formation of the AC is closely linked to the enlargement and remodeling of the nucleus, which wraps around the AC at late times in infection (Figure 1A).