Details

Autor(en) / Beteiligte

• Peters, Brian M
• Shirtliff, Mark E
• Jabra-Rizk, Mary Ann
• Madhani, Hiten D.

Titel

Antimicrobial peptides: primeval molecules or future drugs?

Ist Teil von

• PLoS pathogens, 2010-10, Vol.6 (10), p.e1001067-e1001067

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

•   [...]a mounting body of evidence indicates the presence of additional or complementary mechanisms such as intracellular targeting of cytoplasmic components crucial to proper cellular physiology (Figure 2) [7], [8]. [...]the initial interaction between the peptides and the microbial cell membrane would allow them to penetrate into the cell to bind intracellular molecules, resulting in the inhibition of cell wall biosynthesis and DNA, RNA, and protein synthesis. [...]insights into the mechanisms employed by AMPs will facilitate new approaches to discover and develop pharmacologic agents.