PLoS pathogens, 2010-01, Vol.6 (1), p.e1000728-e1000728
2010
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Details
- Autor(en) / Beteiligte
- Titel
- CD8+ T cell control of HIV--a known unknown
- Ist Teil von
- PLoS pathogens, 2010-01, Vol.6 (1), p.e1000728-e1000728
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2010
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- [...]most of these studies have not explicitly examined the mechanisms by which viral control is achieved. Because of the name ("cytotoxic") and the early assays for detection (measuring cytolysis using chromium release in vitro), it is usually assumed that CD8+ T cells control HIV infection by killing HIV-infected cells. What makes their studies different from previous studies of CD8+ T cell depletion is that they also treated animals with anti-retroviral therapy (ART) after CD8+ T cell depletion. Because ART blocks subsequent rounds of viral infection, it has been used extensively over the last decade to study the turnover of HIV-infected cells [7],[8].
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1553-7374, 1553-7366eISSN: 1553-7374DOI: 10.1371/journal.ppat.1000728Titel-ID: cdi_plos_journals_1289060416
- Format
- –
- Schlagworte
- Animals, CD8-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - virology, Charitable foundations, Control, Cytokines, Cytotoxicity, Health aspects, HIV (Viruses), HIV - immunology, HIV infection, HIV Infections - immunology, Humans, Immune system, Infections, Lymphocytes, Opinion, Peptides, Physiological aspects, Simian Acquired Immunodeficiency Syndrome - immunology, Simian Immunodeficiency Virus - immunology, Studies, T cells, Viral infections