Details

Autor(en) / Beteiligte

• Harboe, Zitta B
• Thomsen, Reimar W
• Riis, Anders
• Valentiner-Branth, Palle
• Christensen, Jens Jørgen
• Lambertsen, Lotte
• Krogfelt, Karen A
• Konradsen, Helle B
• Benfield, Thomas L
• Klugman, Keith P.

Titel

Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study

Ist Teil von

• PLoS medicine, 2009-05, Vol.6 (5), p.e1000081-e1000081

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2009

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD). In a nationwide population-based cohort study of IPD in Denmark during 1977-2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio >or=3, p<0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality. Specific pneumococcal serotypes strongly and independently affect IPD associated mortality.