Proceedings of the National Academy of Sciences - PNAS, 1985-08, Vol.82 (16), p.5255-5259
1985
Details
- Autor(en) / Beteiligte
- Titel
- Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 1985-08, Vol.82 (16), p.5255-5259
- Ort / Verlag
- Washington, DC: National Academy of Sciences of the United States of America
- Erscheinungsjahr
- 1985
- Link zum Volltext
- Quelle
- EZB Free E-Journals
- Beschreibungen/Notizen
- The ability of antibodies raised against disordered short peptides to interact frequently with their cognate sequences in intact folded proteins has raised a major theoretical issue in protein chemistry. We propose to address this issue by using antibodies raised against peptides with identical sequences, but different conformations, in pairs of unrelated proteins of known three-dimensional structure. The general search method presented here enabled us to detect candidate sequences for such immunological studies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.82.16.5255Titel-ID: cdi_pascalfrancis_primary_8470586
- Format
- –
- Schlagworte
- Adenoviruses, Amino acids, Analytical, structural and metabolic biochemistry, ANIMAL PROTEIN, Animals, ANTIBODIES, ANTICORPS, ANTICUERPOS, Antigen-Antibody Complex, Biochemistry, Biological and medical sciences, Calcium binding proteins, Capsid proteins, Coordinate systems, Epitopes - analysis, Fundamental and applied biological sciences. Psychology, General aspects, investigation methods, IMMUNOCHEMISTRY, Models, Molecular, PEPTIDE, Peptide Fragments - immunology, PEPTIDES, PEPTIDOS, PLANT PROTEINS, Protein Conformation, Protein precursors, PROTEINAS DE ORIGEN ANIMAL, PROTEINAS VEGETALES, PROTEINE ANIMALE, PROTEINE VEGETALE, Proteins, Proteins - immunology, Structure-Activity Relationship, Thiosulfate Sulfurtransferase, Ungulates