Details

Autor(en) / Beteiligte

• Yaswen, Linda
• Kulkarni, Ashok B.
• Fredrickson, Torgny
• Mittleman, Barbara
• Schiffmann, Raphael
• Payne, Susan
• Longenecker, Glenn
• Mozes, Edna
• Karlsson, Stefan

Titel

Autoimmune Manifestations in the Transforming Growth Factor-β1 Knockout Mouse

Ist Teil von

• Blood, 1996-02, Vol.87 (4), p.1439-1445

Ort / Verlag

Washington, DC: Elsevier Inc

Erscheinungsjahr

1996

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Targeted disruption of the transforming growth factor-β1 (TGF-β1) gene in mice results in the development of a massive multifocal inflammatory disease in many tissues. Because no detectable pathogen was identified, we examined whether autoimmune mechanisms played a role in initiating or maintaining the inflammatory disease. The serum of TGF-β1 knockout mice contained elevated titers of antibodies to nuclear antigens (ssDNA, dsDNA, Sm, and RNP), as well as reactivity against the 16/6 idiotype (16/6 Id). In addition, Ig deposits were detected in renal glomeruli of TGF-β1 knockout mice. Transplantation of TGF-β1 knockout hematopoietic cells into normal irradiated recipients resulted in a similar profile of autoantibody production as well as in the induction of inflammatory lesions. Our results describe autoimmune activity that ensues when the TGF-β1 cytokine is absent. This is a US government work. There are no restrictions on its use.