Details

Autor(en) / Beteiligte

• Chen, Zixian
• Zhu, Jiangtao
• Xie, Haibo
• Li, Shan
• Wu, Yongming
• Gong, Yuefa

Titel

Palladium-Catalyzed Synthesis of 2-Fluoroalkyl-3-methylene-3H-indoles Through a Domino Carbopalladation/CH Activation Process

Ist Teil von

• Advanced synthesis & catalysis, 2011-02, Vol.353 (2-3), p.325-330

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2011

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• A novel palladium‐catalyzed synthesis of substituted 3‐methylene‐3H‐indoles from readily accessible alkynylimines has been developed. A wide variety of 2‐fluoroalkyl‐3‐methylene‐3H‐indoles were synthesized in moderate to good yields through this cascade carbopalladation/CH activation process. This reaction can also be expanded to non‐fluorinated substrates.